Sertraline (Zoloft) like other SSRIs drugs selectively blocks the reuptake of serotonin presynaptic membrane, which leads to increased concentrations of monoamines in the synaptic cleft, which is responsible for timoanaleptic and anxiolytic effects.

Numerous studies suggest that symptomatic Sertraline has a wide spectrum of action and effective, in addition to depression, and anxiety-phobic, obsessive-compulsive disorders and has a good tolerability profile.

Clinical predictors of Zoloft effectiveness largely coincided with those identified in the study of fluoxetine. The effectiveness of Zoloft was higher with greater severity of symptoms of anxiety and especially psychiatric manifestations. In contrast, fluoxetine did not reveal a negative correlation between the effectiveness of reflecting its adynamic components. It is these symptoms, many authors, including H.van Praag (1991), is associated with dysfunction of the dopaminergic system. As already noted, Zoloft is the most powerful blocker of dopamine reuptake among used antidepressants.

Usually, Zoloft is assigned 1 time per day in the morning or evening. The tablets can be taken irrespective of food intake. In depression and OCD treatment begins with a dose of 50mg/day. With little effect daily dose can be increased gradually (50mg), in a few weeks to a maximum dose of 200mg/day. The initial effect may be observed in 7 days after initiation of treatment, but the overall effect is usually achieved within 2-4 weeks. Treatment of panic disorder and PTSD begin with a dose of 25 mg/day, which increased after 1 week to 50mg/day. Use of the preparation of such a scheme reduces the incidence of early side effects of treatment, specific to panic disorder. When conducting long-term maintenance therapy drug is prescribed in the lowest effective dose, which subsequently is changed depending on the clinical effect.

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